Agios Provides Update on 2016 Collaboration Agreement with Celgene, a Wholly Owned Subsidiary of Bristol Myers Squibb
– Celgene Declines to Exercise Opt-in Right for
– Research Term of the Metabolic Immuno-oncology Collaboration to Conclude at the End of the Initial Four-year Period in
– AG-270 Phase 1 Combination Expansion Trials Ongoing –
“We are grateful to Celgene, and now Bristol Myers Squibb, for their longstanding partnership, which has enabled important research and clinical development focused on the advancement of potential innovative treatment approaches for patients with cancer,” said
“We are proud of the work our scientists have done to significantly advance knowledge in the field of metabolic immuno-oncology, and through these efforts we have built capabilities now being applied across multiple research programs,” said
About the MAT2A Inhibitor AG-270
Agios’ first-in-class MAT2A inhibitor, AG-270, was part of a 2016 global research collaboration agreement with Celgene. Under the terms of the agreement, Celgene had an opt-in right on the program up through the end of Phase 1 dose escalation for at least a
As described in a 2016 Cell Reports publication, Agios discovered that MAT2A is a component of a novel pathway which, when inhibited, results in robust anti-tumor activity in MTAP-deleted tumors in animal models. Further preclinical studies demonstrated that the effects of AG-270 downstream of MAT2A inhibition include effects on mitosis, which creates the potential for enhanced vulnerability to antimitotics, including the clinically-applicable taxanes.
The first data from the single agent dose-escalation arm of the Phase 1 study of AG-270 in MTAP-deleted tumors were presented at the 2019
About the 2016 Metabolic Immuno-Oncology Agreement
There is one ongoing research program that Celgene may designate for continued development within 60 days following the end of the initial four-year research term, which expires on
About the Agios/Celgene IDH Program
In 2010, Agios and Celgene entered into a collaboration agreement focused on cancer metabolism. Under the terms of the agreement, Celgene has worldwide development and commercialization rights for IDHIFA® (enasidenib). Agios continues to conduct certain clinical development activities within the IDHIFA® development program and is eligible to receive reimbursement for those development activities and up to
Agios is focused on discovering and developing novel investigational medicines to treat malignant hematology, solid tumors and rare genetic diseases through scientific leadership in the field of cellular metabolism. In addition to an active research and discovery pipeline across these three therapeutic areas, Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development. For more information, please visit the company's website at www.agios.com.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Agios’ plans, strategies and expectations for its and its collaborator’s preclinical, clinical and commercial advancement of its drug development programs including AG-270; developments regarding its 2016 collaboration agreement with Celgene; and the potential benefit of its strategic plans and focus. The words “anticipate,” “expect,” “goal,” “hope,” “milestone,” “plan,” “potential,” “possible,” “strategy,” “will,” “vision,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from Agios' current expectations and beliefs. For example, there can be no guarantee that any product candidate Agios or its collaborators is developing will successfully commence or complete necessary preclinical and clinical development phases, or that development of any of Agios' product candidates will successfully continue. There can be no guarantee that any positive developments in Agios' business will result in stock price appreciation. Management's expectations and, therefore, any forward-looking statements in this press release could also be affected by risks and uncertainties relating to a number of other important factors, including: Agios' results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the
Director, Investor Relations
Associate Director, Corporate Communications
Source: Agios Pharmaceuticals, Inc.