Schedule of Unrecognized Tax Benefits Rollforward
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Total revenue-related reserves
Contract With Customer, Total Allowances And Reserves
Debt securities in an unrealized loss position
Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Number of Positions, Greater than or Equal to One Year
Operating lease liabilities arising from obtaining operating lease assets
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Inventory Disclosure [Abstract]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Common stock, par value (in usd per share)
Common Stock, Par or Stated Value Per Share
Additional option exercise fee for further development
Additional Option Exercise Fee Receivable
Additional option exercise fee receivable.
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Aggregate period
Period Of Change In Stockholders Ownership
Period of change in stockholders ownership .
Revenue Recognition, Milestone Method [Table]
Revenue Recognition, Milestone Method [Table]
Returns, adjustments relating to prior years
Provision For Right To Recover Product In Prior Years
Summary of Marketable Securities
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Returns
Product Returns [Heading Roll Forward]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Contractual adjustments, adjustments relating to prior years
Prior Year Provision For Contractual Adjustments
Schedule of Market-Based Unit Activity
Schedule of Nonvested Share Activity [Table Text Block]
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Cost and expenses:
Operating Expenses [Abstract]
Share-based Payment Arrangement [Abstract]
Concentrations of credit risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Aggregate intrinsic value, vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Property Plant and Equipment Useful Life and Values [Abstract]
Property Plant and Equipment Useful Life and Values [Abstract]
Depreciation expense
Depreciation
Common stock, shares outstanding (in shares)
Common Stock, Shares, Outstanding
Total cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Additions
Contract With Customer, Asset, Revenue Recognized
2024
Lessee, Operating Lease, Liability, Payments, Due Year Five
Total cash equivalents and marketable securities
Cash Equivalents And Available For Sale Securities
Cash equivalents and available for sale securities.
Income taxes
Income Tax, Policy [Policy Text Block]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Revenue Recognition and Deferred Revenue [Abstract]
Revenue Recognition and Deferred Revenue [Abstract]
Employer's contribution percentage of eligible compensation
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Aggregate intrinsic value, exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Additions
Amounts included in the contract liability at the beginning of the period
Contract with Customer, Liability, Revenue Recognized
Impact of federal rate change
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Rent expense
Operating Leases, Rent Expense
Financing lease liabilities
Finance Lease, Liability, Current
Property and equipment, net
Total property and equipment, net
Property, Plant and Equipment, Net
Aggregate intrinsic value, outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Level 2
Fair Value, Inputs, Level 2 [Member]
Proceeds from stock option exercises in other current assets
Proceeds From Stock Options Exercised In Other Current Assets
Proceeds receivable from stock options exercised in other current assets.
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Weighted-average grant date fair value, vested (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Aurigene Discovery Technologies Limited
Aurigene Discovery Technologies Limited [Member]
Aurigene Discovery Technologies Limited [Member]
Weighted-average exercise price, vested and expected to vest (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Stock options
Stock options
Share-based Payment Arrangement, Option [Member]
Number of stock options, vested and expected to vest (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Opportunity to purchase common stock (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee
Schedule of Impact of New Accounting Pronouncements
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Lease Arrangements [Axis]
Lease Arrangements [Axis]
Lease Arrangements
Expected term (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Number of stock options, forfeited/expired (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Statement [Table]
Statement [Table]
Number of allowable special case extensions
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Special Case Extensions
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Special Case Extensions
Government Rebates
Government Rebates [Heading Roll Forward]
Performance obligations satisfied in previous periods
Contract with Customer, Performance Obligation Satisfied in Previous Period
2007 Plan and 2013 Plan
Two Thousand Seven Stock Incentive Plan And Two Thousand Thirteen Stock Incentive Plan [Member]
Two Thousand Seven Stock Incentive Plan And Two Thousand Thirteen Stock Incentive Plan [Member]
Domestic
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Supplemental disclosure of non-cash investing and financing transactions:
Noncash Investing and Financing Items [Abstract]
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
2022
Lessee, Operating Lease, Liability, Payments, Due Year Three
Share based awards reserved for issuance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Current
Current Asset [Member]
Current asset.
Deferred revenue – related party, current and net of current portion
Contract with Customer, Liability, Related Party, Current [Member]
Development activities
Development Activities [Member]
Development Activities [Member]
Summary of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Weighted-average incremental borrowing rate
Operating Lease, Weighted Average Discount Rate, Percent
Investments, Debt and Equity Securities [Abstract]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
General business credits and other credits
Effective Income Tax Rate Reconciliation Tax Credits Adjustments
Effective income tax rate reconciliation tax credits adjustments.
Operating lease right of use asset
Deferred Tax Liability, Operating Lease, Right-Of-Use Asset
Deferred Tax Liability, Operating Lease, Right-Of-Use Asset
Schedule of Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Lessee, Lease, Description [Line Items]
Lessee, Lease, Description [Line Items]
Operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Other stock awards
Other Stock Awards [Member]
Other Stock Awards
65/35 Program
Program One [Member]
Program one.
Committee participation
Committee Participation [Member]
Committee Participation
Payments on financing lease obligations
Finance Lease, Principal Payments
Schedule of Performance-Based Unit Activity
Schedule of Nonvested Performance-based Units Activity [Table Text Block]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Timing of Transfer of Good or Service [Domain]
Timing of Transfer of Good or Service [Domain]
Accrued professional fees
Accrued Professional Fees, Current
Celgene
Celgene [Member]
Celgene.
Federal Orphan Drug Tax Credit
Federal Orphan Drug Tax Credit [Member]
Federal Orphan Drug Tax Credit [Member]
Specified regulatory milestone events
Regulatory Milestone Events [Member]
Regulatory milestone events.
Designation fee receivable
Designation Fee Receivable
Designation fee receivable.
Schedule of Significant Accounting Policies [Line Items]
Schedule Of Significant Accounting Policies [Line Items]
Schedule Of Significant Accounting Policies.
Entity Public Float
Entity Public Float
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Accrued research and development costs
Accrued Research And Development Costs Current
Accrued research and development costs current.
Financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Interest income, net
Investment Income, Interest
Total stock-based compensation expense
Allocated share based compensation expense
Share-based Payment Arrangement, Expense
Net operating loss carryforwards
Operating Loss Carryforwards
Public Offering
Public Offering [Member]
Public offering.
Offering price (in usd per share)
Shares Issued, Price Per Share
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
38 Sidney Street Lease
Thirty-Eight Sidney Street Lease [Member]
Thirty-Eight Sidney Street Lease
Reduction of research and development costs
Research and Development Arrangement, Contract to Perform for Others, Compensation Earned
Net deferred taxes
Deferred Tax Assets, Net
Operating lease liabilities, net of current portion
Operating Lease, Liability, Noncurrent
Assets
Assets [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Deferred revenue
Deferred Tax Assets, Deferred Income
Statistical Measurement [Axis]
Statistical Measurement [Axis]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Accounts payable
Increase (Decrease) in Accounts Payable
Deferred tax assets
Deferred Income Tax Assets, Net
Total deferred tax assets
Deferred Tax Assets, Gross
Construction in progress
Construction in Progress [Member]
Document Fiscal Year Focus
Document Fiscal Year Focus
Common Stock
Stockholders' Equity Note Disclosure [Text Block]
Revenues:
Revenue from Contract with Customer [Abstract]
Revenue from Contract with Customer [Abstract]
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Unrealized gain (loss) on available-for-sale securities
Unrealized gain on available-for-sale securities
Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
CStone Pharmaceuticals
CStone Pharmaceuticals [Member]
Specified commercial milestone events
Commercial Milestone Events [Member]
Commercial milestone events.
Fair Value Measurements
Fair Value Disclosures [Text Block]
Licenses
License and Service [Member]
Other non-current assets
Other Assets, Noncurrent
Entity Current Reporting Status
Entity Current Reporting Status
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Deferred rent, net of current portion
Deferred Rent Credit, Noncurrent
Entity Emerging Growth Company
Entity Emerging Growth Company
Accumulated Deficit
Retained Earnings [Member]
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Income Tax Authority [Axis]
Income Tax Authority [Axis]
Issuance of common stock for follow-on offering (in shares)
Number of shares issued from public offering (in shares)
Stock Issued During Period, Shares, New Issues
Milestone revenue received
Research and Development Arrangement, Contract to Perform for Others, Milestone Revenue
Research and Development Arrangement, Contract to Perform for Others, Milestone Revenue
Accounts receivable, net
Contract with Customer, Asset, Net, Current
Inventory
Total Inventory
Inventory, Net
Contract Assets and Liabilities [Roll Forward]
Contract Assets And Liabilities [Heading Roll Forward]
Antidilutive securities excluded from computation of earnings per share (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Balance Sheet Location [Axis]
Balance Sheet Location [Axis]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Unrecognized compensation expense related to options
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Government securities
US Government Corporations and Agencies Securities [Member]
2019
Operating Leases, Future Minimum Payments Due, Next Twelve Months
Number of square feet of office space (in square feet)
Lessee, Operating Lease, Number Of Square Feet Of Office Space
Lessee, Operating Lease, Number Of Square Feet Of Office Space
Initial Application Period Cumulative Effect Transition [Axis]
Initial Application Period Cumulative Effect Transition [Axis]
Term for extension of operating lease (in years)
Lessee, Operating Lease, Renewal Term
AG-881 program licenses
Ag 881 Agreements [Member]
Ag 881 agreements.
Non Current
Non Current Assets [Member]
Non current assets.
Licenses
Program Licenses [Member]
Program Licenses [Member]
Increase (decrease) in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Undiscounted minimum rental commitments
Lessee, Operating Lease, Liability, Payments, Due
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
2023
Operating Leases, Future Minimum Payments, Due in Five Years
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Axis]
Reimbursement (payment) of public offering costs
Reiumbursement Of Stock Issuance Costs
Entity Address, State or Province
Entity Address, State or Province
Summary of Company's Stock Option Activity of all Stock Incentive Plans
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Property and equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Schedule of Restricted Stock Unit Activity
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Designation fees received
Designation Fee Income
Designation Fee Income
Property and Equipment, net
Property, Plant and Equipment Disclosure [Text Block]
Government rebates, adjustments relating to prior years
Prior Year Provisions For Rebate Reserve
Proceeds from public offering of common stock, net of reimbursements
Net proceeds from public offering
Proceeds from Issuance of Common Stock
Recent accounting pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Accounts receivable, net
Receivables, Trade and Other Accounts Receivable, Allowance for Doubtful Accounts, Policy [Policy Text Block]
Net loss
Net Income (Loss) Available to Common Stockholders, Basic
Tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards
Document Transition Report
Document Transition Report
Net operating loss, indefinite carryforward
Indefinite Operating Loss Carryforwards
Adjustment to income tax expense related to tax reform
Tax Cuts and Jobs Act, Income Tax Expense (Benefit)
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value measurements
Fair Value Measurement, Policy [Policy Text Block]
Percentage of stock owned resulting in an ownership change
Percentage Of Stockholders Ownership Increase
Percentage of stockholders ownership increase.
Initial Application Period Cumulative Effect Transition [Domain]
Initial Application Period Cumulative Effect Transition [Domain]
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-sale
Total cost and expenses
Operating Expenses
Weighted-average exercise price, granted (in usd per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Cash and cash equivalents at beginning of the period
Cash and cash equivalents at end of the period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Weighted-average grant date fair value of options (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Summary of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name [Domain]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Weighted-average remaining contractual term, outstanding (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Other Than 65/35 Program
Program Two [Member]
Program two.
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense
Document Annual Report
Document Annual Report
Adjustments for New Accounting Pronouncements [Axis]
Adjustments for New Accounting Pronouncements [Axis]
Expected contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Percentage of outstanding shares of common stock (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Annual Increase Percentage In Number Of Shares Available For Grant
Share based compensation arrangement by share based payment award annual increase percentage in number of shares available for grant.
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Cumulative Effect and Effect of Change
Difference between Revenue Guidance in Effect before and after Topic 606 [Member]
Specified clinical development event
Clinical Development Event [Member]
Clinical development event.
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Impairment of long-lived assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Investment maturity period, non-current
Available For Sale Securities Non Current Maturity Period
Available for sale securities non current maturity period.
Cash paid for amounts included in measurement of lease liabilities
Operating Lease, Payments
Geographical [Axis]
Geographical [Axis]
Schedule of Product Revenue
Revenue From Contracts With Customers, Product Revenue [Table Text Block]
Revenue From Contracts With Customers, Product Revenue
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Lease Arrangements [Domain]
Lease Arrangements [Domain]
Lease Arrangements
Net accretion of discount on marketable securities
Accretion (Amortization) of Discounts and Premiums, Investments
Loss on disposal of property and equipment
Gain (Loss) on Disposition of Assets
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Additional shares authorized for issuance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized
Level 3
Fair Value, Inputs, Level 3 [Member]
Entity Address, City or Town
Entity Address, City or Town
Estimated Useful Lives of Property and Equipment
Schedule Of Property Plant And Equipment Estimated Useful Life [Table Text Block]
Schedule of property plant and equipment estimated useful life.
Tax benefits related to stock based compensation
Share-based Payment Arrangement, Expense, Tax Benefit
Estimated useful lives of property and equipment
Property, Plant and Equipment, Useful Life
Less: valuation allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Contractual adjustments, payments/returns relating to sales in the current year
Contract With Customer, Contract Adjustment, Recoveries, Current Year
Entity Filer Category
Entity Filer Category
Entity Voluntary Filers
Entity Voluntary Filers
Total minimum rental commitments
Operating Leases, Future Minimum Payments Due
Equity [Abstract]
Inventory write-downs
Inventory Write-down
Schedule of Significant Accounting Policies [Table]
Schedule Of Significant Accounting Policies [Table]
Schedule Of Significant Accounting Policies [Table]
Government rebates, payments/returns relating to sales in the prior years
Contract With Customer Rebate Reserve, Recoveries In Prior Years
Schedule of Product Revenue Allowance and Reserves
Schedule of Accounts, Notes, Loans and Financing Receivable [Table Text Block]
Summary of Quarterly Financial Data
Quarterly Financial Information [Table Text Block]
Contractual adjustments, payments/returns relating to sales in the prior year
Contract With Customer, Contract Adjustment, Recoveries, Prior Year
Research and development costs
Research and Development Expense, Policy [Policy Text Block]
Number of ownership changes
Number Of Changes In Stockholders Ownership
Number of changes in stockholders ownership.
Income Tax Disclosure [Abstract]
Sale of Stock [Domain]
Sale of Stock [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Comprehensive loss
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Statement [Line Items]
Statement [Line Items]
Under Topic 605
Calculated under Revenue Guidance in Effect before Topic 606 [Member]
Entity Registrant Name
Entity Registrant Name
Furniture and fixtures
Furniture and Fixtures [Member]
Government rebates, beginning balance
Government rebates, ending balance
Contract With Customer, Rebate Reserve
Marketable securities
Marketable Securities, Policy [Policy Text Block]
Total allowances and reserves, current provisions relating to sales in the current year
Contract With Customer, Current Year Reserve Provisions
CStone Agreement
CStone Agreement [Member]
Shares issued under 2013 ESPP (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Over-Allotment Option
Over-Allotment Option [Member]
Amendment Flag
Amendment Flag
Gross increases - current period tax positions
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Marketable securities
Debt Securities, Available-for-sale, Noncurrent
City Area Code
City Area Code
Change In Contract With Customer, Asset [Roll Forward]
Change In Contract With Customer, Asset1 [Heading Roll Forward]
Sale of Stock [Axis]
Sale of Stock [Axis]
Royalty revenue – related party
Royalty [Member]
Office equipment
Office Equipment [Member]
64 Sidney Street Lease
Sixty-Four Sidney Street Lease [Member]
Sixty-Four Sidney Street Lease
Shares available for future issuance under 2013 ESPP (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Entity Central Index Key
Entity Central Index Key
Accrued other
Other Accrued Liabilities, Current
Segment and geographic information
Segment Reporting, Policy [Policy Text Block]
Reimbursement (payment) of public offering costs
Payments of Stock Issuance Costs
Deferred tax assets:
Deferred Tax Assets, Net of Valuation Allowance [Abstract]
Accumulated Other Comprehensive Income (Loss)
AOCI Attributable to Parent [Member]
ASU 2016-02
Accounting Standards Update 2016-02 [Member]
Balance Sheet Location [Domain]
Balance Sheet Location [Domain]
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)
Weighted Average Number of Shares Outstanding, Basic and Diluted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Potential milestone revenue
Revenue From Contracts With Customers, Milestone Revenue Recognized
Revenue From Contracts With Customers, Milestone Revenue Recognized
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Company's Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Incentive stock options
Effective Income Tax Rate Reconciliation, Tax Expense (Benefit), Share-based Payment Arrangement, Percent
Products and Services [Domain]
Product and Service [Domain]
Type of Adoption [Domain]
Type of Adoption [Domain]
Returns, payments/returns relating to sales in the current year
Contract With Customer Right To Recover Product, Current Year Recoveries
Accumulated other comprehensive income (loss)
AOCI, Debt Securities, Available-for-sale, Adjustment, after Tax
Fair Value Disclosures [Abstract]
Inventory
Inventory Disclosure [Text Block]
No. of Performance Obligation(s)
Revenue Recognition Number Of Performance Obligations
Entity Shell Company
Entity Shell Company
Payables and Accruals [Abstract]
Cash and cash equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Special case extension term
Revenue Recognition, Multiple-deliverable Arrangements, Special Case Extension Term
Revenue Recognition, Multiple-deliverable Arrangements, Special Case Extension Term
Deferred rent
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Deferred Rent
Non-US
Non-US [Member]
Stock-based compensation
Share-based Payment Arrangement [Policy Text Block]
Annual increase in common stock (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Annual Increase In Number Of Shares Available For Grant
Share based compensation arrangement by share based payment award annual increase in number of shares available for grant.
Total stockholders’ equity
Beginning balance
Ending balance
Total stockholders’ equity
Stockholders' Equity Attributable to Parent
Subsequent events
Subsequent Events, Policy [Policy Text Block]
Number of federal, state or foreign audits in process
Number Of States Federal Or Foreign In Auditing Process
Number of states, federal or foreign in auditing process.
Collaboration receivable – related party
Increase (Decrease) in Collaboration Receivable, Due from Related Parties, Current
Increase (Decrease) in Collaboration Receivable, Due from Related Parties, Current
Royalty receivable – related party
Royalty Receivable, Due from Related Parties, Current
Royalty Receivable, Due from Related Parties, Current
Work-in-process
Inventory, Work in Process, Net of Reserves
2021
Lessee, Operating Lease, Liability, Payments, Due Year Two
Plan Name [Axis]
Plan Name [Axis]
Schedule of Satisfied and Unsatisfied Performance Obligations
Revenue Performance Obligation [Table Text Block]
Product Revenue
Revenue from Contract with Customer [Text Block]
Investments [Domain]
Investments [Domain]
State and Local Jurisdiction
State and Local Jurisdiction [Member]
Equity Component [Domain]
Equity Component [Domain]
Weighted-average exercise price, exercisable (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Fair Value Hierarchy [Domain]
Fair Value Hierarchy and NAV [Domain]
Certificates of deposit
Certificates of Deposit [Member]
Total property and equipment
Property, Plant and Equipment, Gross
Common Stock
Common Stock [Member]
Revenue from contracts with customers
Revenue from Contract with Customer [Policy Text Block]
Geographical [Domain]
Geographical [Domain]
Schedule of Available-for-sale Securities [Table]
Schedule of Available-for-sale Securities [Table]
Number of stock options, exercisable (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Unrecognized compensation cost not expected to be recognized
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not Expected To Be Recognized, Amount
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not Expected To Be Recognized, Amount
Accounts payable
Accounts Payable, Current
Property, Plant and Equipment [Abstract]
Milestone-based receivable payments, eligible to be received
Revenue Recognition, Milestone Method, Eligible Receivable
Revenue Recognition, Milestone Method, Eligible Receivable
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Cumulative Effect of Accounting Changes [Abstract]
Cumulative Effect Of Accounting Changes [Abstract]
Current Fiscal Year End Date
Current Fiscal Year End Date
DHODH Phase One Clinical Trial
DHODH Phase One Clinical Trial [Member]
DHODH Phase One Clinical Trial [Member]
Intrinsic value of options exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Cash, cash equivalents and marketable securities
Cash, Cash Equivalents, and Short-term Investments
Income Tax Authority [Domain]
Income Tax Authority [Domain]
Equity Award [Domain]
Award Type [Domain]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
2010 Agreement
Agreement 2010 [Member]
Agreement 2010 [Member]
Weighted-average grant date fair value, granted (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Additional paid-in capital
Additional Paid in Capital, Common Stock
Inventory
Inventory, Policy [Policy Text Block]
Reduction of accounts receivable
Accounts Receivable, Allowance for Credit Loss, Current
Less: accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Schedule of Changes in Contract Assets and Liabilities
Contract With Customer, Asset And Liability, Product Revenue [Table Text Block]
Finished goods
Inventory, Finished Goods, Net of Reserves
Number of stock options, granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Level 1
Fair Value, Inputs, Level 1 [Member]
Amortized Cost
Debt Securities, Available-for-sale, Amortized Cost
Net proceeds from stock option exercises and employee stock purchase plan
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised
Reconciliation of Expected Income Tax Benefit (Expense) Computed Using Federal Statutory Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Share-Based Payments
Share-based Payment Arrangement [Text Block]
Royalty receivable – related party
Royalty Receivable, Due From Related Parties, Current [Member]
Cost of Sales
Cost of Goods and Service [Policy Text Block]
Total allowances and reserves, payments/returns relating to sales in the prior years
Contract With Customer, Prior Years Reserve Recoveries
Contractual adjustments, current provisions relating to sales in the current year
Current Year Provision For Contractual Adjustments
Upfront payment agreement extension fee receivable
Upfront Payment Agreement Extension Fee Receivable
Upfront payment agreement extension fee receivable.
Transferred at Point in Time
Transferred at Point in Time [Member]
Income Statement Location [Axis]
Income Statement Location [Axis]
Contract assets, beginning balance
Contract assets, ending balance
Contract with Customer, Asset, after Allowance for Credit Loss
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Lessee, Lease, Description [Table]
Lessee, Lease, Description [Table]
Employee Stock Purchase Plan
Employee Stock Purchase Plan shares
Employee Purchase Plan [Member]
Employee Purchase Plan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Option exercise fee receivable
Option Exercise Fee Receivable
Option exercise fee receivable
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Number of stock options, outstanding, beginning balance (in shares)
Number of stock options, outstanding, ending balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Summary of Collaboration Revenue
Revenue Recognition Multiple Deliverable Arrangements Allocated By Performance Obligation [Table Text Block]
Tenant improvement allowance
Lessee, Operating Lease, Tenant Improvement Allowance
Lessee, Operating Lease, Tenant Improvement Allowance
Thereafter
Lessee, Operating Lease, Liability, Payments, Due after Year Five
Prepaid expenses and other current and non-current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Investment Type [Axis]
Investment Type [Axis]
Fair Value, Measurements, Recurring
Fair Value, Recurring [Member]
Leasehold improvements
Leasehold Improvements [Member]
Realized gain (loss) on marketable securities
Marketable Securities, Realized Gain (Loss)
Loss from operations
Loss from operations
Operating Income (Loss)
Total operating lease liabilities
Total operating lease liabilities
Operating Lease, Liability
Tax Credit Carryforward [Axis]
Tax Credit Carryforward [Axis]
Component of accrued expenses
Contract With Customer, Allowance And Reserves, Liability
Commitments and Contingencies Disclosure [Abstract]
Weighted-average period to recognize compensation expense
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Inventory
Increase (Decrease) in Inventories
Net loss per share - basic and diluted (in usd per share)
Earnings Per Share, Basic and Diluted
Collaboration receivable – other
Collaboration Receivable, Other, Current
Collaboration revenue – related party
Collaboration Revenue, Related Party [Member]
Unvested shares beginning of period (in shares)
Unvested shares end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Proceeds from maturities and sales of marketable securities
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale
Subsequent Event
Subsequent Event [Member]
Weighted-average remaining contractual term, vested and expected to vest (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Accrued compensation
Employee-related Liabilities, Current
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Aggregate fair value of debt securities in an unrealized loss position
Available-for-sale Securities, Continuous Unrealized Loss Position, Fair Value
Schedule of Undiscounted Minimum Rental Commitments Under Topic 840
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Issuance of common stock for follow-on offering
Stock Issued During Period, Value, New Issues
Commitments and contingent liabilities (Note 9)
Commitments and Contingencies
Statement of Stockholders' Equity [Abstract]
Cover page.
Schedule of Domestic and Foreign Components of Loss Before Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Research and development
Upfront payment for research and development
Research and Development Expense
Revenue, Initial Application Period Cumulative Effect Transition [Table]
Revenue, Initial Application Period Cumulative Effect Transition [Table]
Minimum period to liquidate
Available For Sale Securities Non Current Minimum Liquidating Period
Available for sale securities non current minimum liquidating period.
Initial payment received
Contract With Customer, Liability, Increase From Cash Receipts
Total liabilities
Total liabilities
Liabilities
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
2021
Operating Leases, Future Minimum Payments, Due in Three Years
Interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Total
Accounts Receivable, Allowance for Credit Loss [Roll Forward]
U.S. Treasuries
US Treasury Securities [Member]
Trading Symbol
Trading Symbol
Government rebates, current provisions relating to sales in the current year
Current Year Provisions For Rebate Reserve
Government rebates, payments/returns relating to sales in the current year
Contract With Customer Rebate Reserve, Recoveries In Current Year
Number of programs that may be designated for continued development for which development candidates have yet to be nominated
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Research Programs That Can Be Designated For Continued Development After The Research Term
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Research Programs That Can Be Designated For Continued Development After The Research Term
Additions to property and equipment in accounts payable and accrued expenses
Capital Expenditures Incurred but Not yet Paid
Document Period End Date
Document Period End Date
Returns, payments/returns relating to sales in the prior years
Contract With Customer Right To Recover Product, Prior Year Recoveries
Quarterly Financial Information Disclosure [Abstract]
Deferred revenue - related party, current and net of current portions
Contract liabilities, beginning balance
Contract liabilities, ending balance
Contract with Customer, Liability
Financing lease liabilities, net of current portion
Finance Lease, Liability, Noncurrent
Financing lease liabilities arising from obtaining financing lease assets
Right-of-Use Asset Obtained in Exchange for Finance Lease Liability
2023
Lessee, Operating Lease, Liability, Payments, Due Year Four
Operating lease liability
Deferred Tax Assets, Operating Lease Liability
Deferred Tax Assets, Operating Lease Liability
Adjustment to beginning accumulated deficit resulting from adoption of ASC 606
Cumulative Effect of New Accounting Principle in Period of Adoption
Deferred rent
Deferred Rent Credit, Current
Royalty percentage
Royalty Percentage Remitted
2020
Lessee, Operating Lease, Liability, Payments, Due Next Twelve Months
ASU 2014-09
Accounting Standards Update 2014-09 [Member]
2013 Stock Incentive Plan
Two Thousand And Thirteen Stock Incentive Plan [Member]
Two thousand and thirteen stock incentive plan.
Project [Axis]
Project [Axis]
Common stock, $0.001 par value; 125,000,000 shares authorized and 68,401,105 and 58,218,653 shares issued and outstanding at December 31, 2019 and 2018, respectively
Common Stock, Value, Issued
Comprehensive income (loss)
Comprehensive Income, Policy [Policy Text Block]
Research and development expense
Research and Development Expense [Member]
Other services
Service, Other [Member]
Other services
Other Services [Member]
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Operating lease liabilities
Increase (Decrease) In Operating Lease, Liability
Increase (Decrease) In Operating Lease, Liability
Laboratory equipment
Laboratory Equipment [Member]
Laboratory equipment.
Collaboration receivable – related party
Collaboration Receivable, Due from Related Parties, Current
Collaboration Receivable, Due from Related Parties, Current
Cost of sales
Cost of Goods and Services Sold
Revenue Recognition, Milestone Method [Line Items]
Revenue Recognition, Milestone Method [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Total assets
Total assets
Assets
Total marketable securities
Fair Value
Debt Securities, Available-for-sale
Co-Development and Co-Commercialization Agreements
Co-development and Co-commercialization Agreements [Member]
Co-development and co-commercialization agreements.
Project [Domain]
Project [Domain]
Weighted-average remaining contractual term, exercisable (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Plan Name [Domain]
Plan Name [Domain]
Transferred over Time
Transferred over Time [Member]
Research Tax Credit Carryforward
Research Tax Credit Carryforward [Member]
Revenue from remaining performance obligations
Stand alone selling price
Revenue, Remaining Performance Obligation, Amount
Commercialization Activities
Commercialization Activity [Member]
Commercialization Activity
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Document Fiscal Period Focus
Document Fiscal Period Focus
Document Type
Document Type
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Collaboration receivable – related party
Collaboration Receivable, Due From Related Parties, Current [Member]
Timing of Transfer of Good or Service [Axis]
Timing of Transfer of Good or Service [Axis]
Summary of Performance Obligations, CStone Agreement
Revenue Performance Obligation CStone Agreement [Table Text Block]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Entity Tax Identification Number
Entity Tax Identification Number
Income Statement [Abstract]
Income Statement [Abstract]
Leases
Lessee, Operating Leases [Text Block]
Product revenue, net
Product [Member]
Permanent differences and other adjustments
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Total
Effective Income Tax Rate Reconciliation, Percent
2013 Employee Stock Purchase Plan
Employee Stock Purchase Plan 2013 [Member]
Employee Stock Purchase Plan 2013 [Member]
Total cost and expenses
Costs and Expenses
Entity Interactive Data Current
Entity Interactive Data Current
Foreign rate differential
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Accrued expenses
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Corporate debt securities
Corporate Debt Securities [Member]
Number of operating segments
Number of Operating Segments
Provision for income taxes
Income Tax Expense (Benefit)
Use of estimates
Use of Estimates, Policy [Policy Text Block]
Non-cash operating lease expense
Operating Lease, Right-Of-Use Asset, Amortization
Operating Lease, Right-Of-Use Asset, Amortization
Fair Value, Hierarchy [Axis]
Fair Value Hierarchy and NAV [Axis]
Contractual adjustments, beginning balance
Contractual adjustments, ending balance
Contract With Customer, Contractual Adjustment Reserve
Total current assets
Total current assets
Assets, Current
Schedule of Undiscounted Minimum Rental Commitments Under Topic 842
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Deferred revenue, net of current portion – related party
Contract with Customer, Liability, Noncurrent
Net change in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Number of optional terms available at end of current lease term (in lease terms)
Lessee, Operating Lease, Number Of Lease Terms
Lessee, Operating Lease, Number Of Lease Terms
Total current liabilities
Total current liabilities
Liabilities, Current
ASU 2016-09
Accounting Standards Update 2016-09 [Member]
Returns, beginning balance
Returns, ending balance
Contract With Customer, Right To Recover Product, Reserve
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Domain]
Purchased intangible assets
Deferred Tax Assets, Goodwill and Intangible Assets
Local Phone Number
Local Phone Number
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Total liabilities and stockholders’ equity
Total liabilities and stockholders’ equity
Liabilities and Equity
Milestone payment for filing of first NDA
Portion Of Potential Milestone Payment Receivable For Filing Of New Drug Application
Portion of potential milestone payment receivable for filing of new drug application.
Extension period
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Extensions
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Extensions
2020
Operating Leases, Future Minimum Payments, Due in Two Years
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Nature of Business
Nature of Operations [Text Block]
Minimum option exercise fee receivable for continuation program
Option Exercise Fee Receivable For Continuation Program
Option exercise fee receivable for continuation program.
Computer equipment and software
Computer Equipment And Software [Member]
Computer equipment and software.
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity Components [Axis]
Equity Components [Axis]
Returns, current provisions relating to sales in the current year
Provision For Right To Recover Product In Current Year
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Schedule of Inventory
Schedule of Inventory, Current [Table Text Block]
Weighted-average grant date fair value, forfeited/expired (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Schedule of Grant Date Fair Value Option Award Weighted Average Assumptions Used
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Collaboration receivable – other
Collaboration receivable – other
Increase (Decrease) in Collaboration Receivable, Other, Current
Award Type [Axis]
Award Type [Axis]
Defined Contribution Benefit Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Schedule of Stock-Based Compensation Expense by Award Type Included Within the Condensed Consolidated Statements of Operations
Share-based Payment Arrangement, Cost by Plan [Table Text Block]
Counterparty Name [Domain]
Counterparty Name [Domain]
Income tax benefit computed at federal statutory tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Accounts receivable, net
Increase (Decrease) in Contract with Customer, Asset
Depreciation and amortization
Deferred Tax Liabilities, Property, Plant and Equipment
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Operating lease assets
Operating right of use assets
Operating Lease, Right-of-Use Asset
Preferred stock, par value (in usd per share)
Preferred Stock, Par or Stated Value Per Share
Thereafter
Operating Leases, Future Minimum Payments, Due Thereafter
Employer's matching contribution percentage
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Investment maturity period, current
Available For Sale Securities Current Maturity Period
Available for sale securities current maturity period.
Weighted-average exercise price, outstanding, beginning balance (in usd per share)
Weighted-average exercise price, outstanding, ending balance (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Foreign Income Tax
Foreign Tax Authority [Member]
Other
Stockholders' Equity, Other
Preferred stock, $0.001 par value; 25,000,000 shares authorized, no shares issued and outstanding at December 31, 2019 and 2018
Preferred Stock, Value, Issued
Profit or loss share percentage
Profit Loss Share Percentage
Profit loss share percentage.
Celegne Agreements
Celegne Agreements [Member]
Celegne Agreements
Milestone payments upon achievement of specified regulatory milestone events
Portion Of Potential Milestone Payment Receivable For Specified Regulatory Milestone Events Program
Portion of potential milestone payment receivable for specified regulatory milestone events program.
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Total
Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest
Deferred revenue – related party
Increase (Decrease) in Contract with Customer, Liability, Related Party
Raw materials
Inventory, Raw Materials, Net of Reserves
Research and development tax credit
Tax Credit Carryforward, Amount
Deductions
Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Measure of Progress
Other Services, Non-Performance Obligations
Service, Other, Non-Performance Obligations [Member]
Service, Other, Non-Performance Obligations
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Entity Small Business
Entity Small Business
Selected Quarterly Financial Data (Unaudited)
Quarterly Financial Information [Text Block]
Entity File Number
Entity File Number
Leases
Lessee, Leases [Policy Text Block]
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Schedule of Available-for-sale Securities [Line Items]
Debt Securities, Available-for-sale [Line Items]
Operating lease liabilities
Operating Lease, Liability, Current
Commitments and Contingent Liabilities
Commitments and Contingencies Disclosure [Text Block]
Beginning balance (in shares)
Ending balance (in shares)
Shares, Outstanding
Principles of consolidation
Consolidation, Policy [Policy Text Block]
Schedule of Royalty Revenue
Revenue From External Customers, Royalty Revenue [Table Text Block]
Weighted-average exercise price, forfeited/expired (in usd per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Accrued expenses
Total accrued expenses
Accrued Liabilities, Current
On-going research and development services
Research Services [Member]
Performance-based stock units
Performance Stock Unit [Member]
Performance Stock Unit [Member]
Schedule of Milestone-Based Payments Associated With 2016 Agreement
Revenue From Contracts With Customers, Milestone Revenue [Table Text Block]
Revenue From Contracts With Customers, Milestone Revenue
Stock-Based Compensation Expense for Employee and Non-Employee Stock Options, Restricted Stock Units, Performance-Based Stock Options, Performance-Based Stock Units and Employee Stock Purchase Plan Shares
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Counterparty Name [Axis]
Counterparty Name [Axis]
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Products and Services [Axis]
Product and Service [Axis]
Depreciation and amortization
Depreciation, Depletion and Amortization
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Federal
Domestic Tax Authority [Member]
Financing lease assets
Finance Lease, Right-of-Use Asset
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Standby letter of credit
Letters of Credit Outstanding, Amount
Milestone payment upon achievement of a specified commercial milestone event
Portion Of Potential Milestone Payment Receivable For Specified Commercial Milestone Event Program
Portion of potential milestone payment receivable for specified commercial milestone event program.
Co Commercial Agreement
Co Commercial Agreement [Member]
Co-commercial agreement.
Contractual Adjustments
Contractual Adjustments [Heading Roll Forward]
Common Stock Excluded from Calculation of Diluted Earnings Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Current liabilities:
Liabilities, Current [Abstract]
Selling, general and administrative expense
Selling, General and Administrative Expenses [Member]
2016 Agreement
Master Research And Collaboration Agreement [Member]
Master research and collaboration agreement.
Cash Equivalents and Marketable Securities Measured at Fair Value on a Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Unrealized Gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Selling, general and administrative
Selling, General and Administrative Expense
Issuance of common stock under stock incentive and employee stock purchase plan (in shares)
Number of stock options, exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Collaboration revenue – other
Collaboration Revenue, Other [Member]
Weighted-average grant date fair value, unvested shares beginning of period (in usd per share)
Weighted-average grant date fair value, unvested shares end of period (in usd per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Potential future milestone payments
Research and Development Arrangement, Contract to Perform for Others, Potential Milestone Payable
Research and Development Arrangement, Contract to Perform for Others, Potential Milestone Payable
Revenues
Total revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Number of cancer metabolism programs discovered under previous agreement, now governed by current agreement
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Programs Discovered Under Previous Agreement, Now Governed By Current Agreement
Revenue Recognition, Multiple-deliverable Arrangements, Number Of Programs Discovered Under Previous Agreement, Now Governed By Current Agreement
Income Taxes
Income Tax Disclosure [Text Block]
Fair value of assets (liabilities)
Fair Value, Net Asset (Liability)
2022
Operating Leases, Future Minimum Payments, Due in Four Years
Term of optional lease (in years)
Lessee, Operating Lease, Term of Contract
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Unrealized Losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Change in Contract with Customer, Liability [Roll Forward]
Change In Contract With Customer, Liability [Heading Roll Forward]
Weighted-average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Net loss per share
Earnings Per Share, Policy [Policy Text Block]
Deferred revenue – related party
Contract with Customer, Liability, Current
Earnings Per Share [Abstract]
Deferred rent
Increase (Decrease) in Deferred Charges
Leases [Abstract]
Weighted-average exercise price, exercised (in usd per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Initial research term
Revenue Recognition, Multiple-deliverable Arrangements, Term Of Agreement
Revenue Recognition, Multiple-deliverable Arrangements, Term Of Agreement
Minimum
Minimum [Member]
Retirement Benefits [Abstract]
Security Exchange Name
Security Exchange Name
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Entity Address, Address Line One
Entity Address, Address Line One
Current assets:
Assets, Current [Abstract]
Unrecognized tax benefits, beginning balance
Unrecognized tax benefits, ending balance
Unrecognized Tax Benefits
Operating lease cost
Operating Lease, Cost
Marketable securities
Debt Securities, Available-for-sale, Current
Number of ongoing legal proceedings
Number Of Legal Proceedings That Have Material Effect
Number of legal proceedings that have material effect.
Issuance of common stock under stock incentive and employee stock purchase plans
Stock Issued During Period, Value, Stock Options Exercised
Deductions
Contract With Customer Asset Proceeds From Collection Of Receivables
Fair Value, Measurement Frequency [Domain]
Measurement Frequency [Domain]
Statement of Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
Schedule of Revenue Related Reserves
Schedule Of Accounts Notes Loans And Financing Receivable1 [Table Text Block]
Non-deductible accruals and reserves, including inventory
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Reserves
Net Loss per Share
Earnings Per Share [Text Block]
Collaboration and License Agreements
Collaborative Arrangement Disclosure [Text Block]
Market-based stock units
Market-Based Stock Units [Member]
Market-Based Stock Units
Cash equivalents
Cash Equivalents [Member]
Unrecognized compensation expense excluding options
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Schedule of Changes in Contract Assets and Liabilities
Contract with Customer, Asset and Liability [Table Text Block]
Total allowances and reserves, adjustments relating to prior years
Contract With Customer, Prior Years Reserve Provisions
Total allowances and reserves, payments/returns relating to sales in the current year
Contract With Customer, Current Year Reserve Recoveries
Royalty receivable – related party
Increase (Decrease) in Royalty Receivable, Due from Related Parties, Current
Increase (Decrease) in Royalty Receivable, Due from Related Parties, Current
Maximum
Maximum [Member]
Title of 12(b) Security
Title of 12(b) Security